Medical Faculty Journal of

Guilan University of Medical Sciences

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Topical Antibiotic Resistance in Kerman

 Burning Center

Zeinali nezhad H., Ramzani A., Dehghani M.R., Gorgani neghad Moshizi M.

ABSTRACT :

Introduction: Infection is the most common complication of burn and one of the most important causes of mortality and morbidity in burned patients. Topical antibiotics have important role in prevention and treatment of infection and reduction of mortality in burned patients. Increases of use of antibiotics cause microbial resistance.

Methods: To determine microbial resistance to three topical antibiotics Silver Nitrate, Silver Sulfadiazine and Mafenide Acetate in the center of burning accident in Kerman a cross- sectional study with 145 during 4 months was designed. After 3 days biopsy was taken from burned site and after culture and determination of microorganism, antibiogram test was done.

Results: Data were shown that the most common microorganism were Klebsiella, Pseudomonas and S.areous. The most effective topical antibiotic was Mafenide Acetate and Silver Nitrate was the most resistant topical antibiotic. There was statistically significant difference between these topical antibiotics in resistant against microorganisms. (P<0.05)

Conclusion: The results as other studies determined Mafenide Acetate is the best topical antibiotic in prevention of burn infection.

Key words: Antibiotics/ Burns/ Infection/ Mafenide/ Silver Nitratey/ Silver Sulfadizine

 Last Update :  October 26, 2003